MLXIPL and Insulin resistance: While SREBF1 is stimulated by insulin (even under conditions of insulin resistance) via mammalian target of rapamycin (mTOR) and by liver X receptor α (LXRα, encoded by Nr1h3), MLXIPL signaling is induced by dietary glucose (even more potently by dietary fructose) independently of insulin or dietary fat [33,34,35].