This pathway of action was studied using natural compounds such as resveratrol, a dietary phenolic compound which reduced the effectiveness of paclitaxel, one of the usual chemotherapeutics agents in BC, and this reduction was mediated by up-regulation of the SIRT1/FoxO1 pathway in MDA-MB-231 and SK-BR-3 cells [27]. Here, FOXO1 is linked to breast cancer.