Interestingly, the mammosphere characterization showed that the capacity of self-renewal was only reduced in the TNBC phenotype-like cell line (MDA-MB-231) and the HER-2 positive cell line (SKBR-3), that are representative of BC tumors with worst prognosis and more aggressivity than the luminal A cell line, MCF-7 [5,6,8,11], in which the β-conglutins treatment had no significant effect. Here, ERBB2 is linked to breast cancer.