Some scholars found that growth hormone-releasing peptide can reduce the oxidative stress response of hypertensive rats by inhibiting PI3K/Akt/mTOR signaling pathway, ameliorate myocardial fibrosis, and improve hypertension; In the process of captopril treatment of hypertension, miR-506 enhances the antioxidant capacity of the body by interacting with PI3K/Akt signaling system, thereby promoting cardiac remodeling in spontaneously hypertensive rats [49]. This evidence concerns the gene AKT1 and Hypertension.