The potential central molecular mechanisms of luteolin in improving hypertension may be through inhibition of NF-κB activity, decrease in inflammatory cytokines, reduction of NAD(P)H-dependent ROS production, improvement of imbalance between neurotransmitters and ameliorate PI3K/Akt signaling pathway in the PVN, as summarized in Figure 9. The gene discussed is AKT1; the disease is Hypertension.