CXCL8 and dermatitis: Excessive UVB irradiation can cause the excessive secretion and up-regulation of inflammatory signalling factors such as TNF-α, IL-1β and IL-8 in keratinocytes [15], leading to skin inflammation, which in turn affects the normal function of the skin barrier, leading to skin homeostasis imbalance, dry and red appearance, and desquamation [16,17].