IL1B and Alzheimer disease: Studies have shown that Aβ and NFT can induce chronic and persistent neuroinflammation in AD patients, which is characterized by activation of macrophages in the brain, induction of excessive secretion of pro-inflammatory cytokines and chemokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor [7].