Grifolin, a farnesyl phenolic compound extracted from the mushrooms A. confluens and Boletus pseudocalopus, which previously suppressed the growth and metastasis of HeLa, MCF-7, SW480, K562, and MG63 tumour cell lines, was reported to decrease the amount of glucose used for lactate production in LMP1-positive cells by targeting DNMT1 to demethylate and reactivate the PTEN gene (Figure 3). Here, DNMT1 is linked to neoplasm.