RNF168 and breast carcinoma: For example, high-level forkhead box M1 (FOXM1) expression can enhance the drug resistance of cancer cells, and studies have shown that RNF168 can promote K48-linked ubiquitination of FOXM1 and reduce the protein level of FOXM1 by promoting its degradation, thus enhancing the sensitivity of breast cancer to Epirubicin [42].