A recent study showed that a 1,2,3-triazole derivative of quinazoline can directly bind with autophagy-related protein SQSTM1/P62 and E3 ligase RNF168, promote their interaction, and damage the DNA repair mediated by RNF168, thus increasing the sensitivity of colon cancer cell HCT-116 to X-ray radiation. This evidence concerns the gene SQSTM1 and malignant colon neoplasm.