In addition, the RNF168 function can be modulated by viral proteins, such as the BMRF1 protein of Epstein–Barr virus (EBV) inhibiting the recruitment of RNF168 in DSB and histone ubiquitination [54], and human papillomavirus E7 oncoprotein directly binding to RNF168 without affecting its enzymatic activity by targeting a new regulatory domain of RNF168, by which tumor viruses reshape the cellular response to DNA damage [55]. The gene discussed is RNF168; the disease is neoplasm.