The current study was to investigate the effects hibiscetin against 3-NPA-induced HD in rodents by evaluating the biochemical alterations, i.e., glutathione (GSH), superoxide dismutase (SOD), catalase activity (CAT), lipid peroxidation (LPO), GSSG reductase (GR), and inflammatory markers, i.e., tumor necrosis factor alpha (TNF-α), interleukins beta (IL-1β), and myeloperoxidase (MPO). This evidence concerns the gene GSR and Huntington disease.