WM-127 was identified based on matrine, an alkaloid found in plants from the genus of Sophora Flavescens, using a survivin-promoter/regulatory-sequence-driven EGFP (Sur5P-EGFP-Sur3U) reporter system in the hepatocellular carcinoma (HCC) HepG2 cell line [143]. The gene discussed is BIRC5; the disease is hepatocellular carcinoma.