Recently, Li et al. reported that DDX5 (also known as p68) could be the direct target of FL118, and they showed that FL118 binds to and inhibits both the phosphorylation and expression of DDX5 in colorectal cancer (CRC) and pancreatic ductal adenocarcinoma (PDAC) cancer [133]. The gene discussed is DDX5; the disease is colorectal cancer.