LQZ-7F (14) is a lead compound, obtained through further analysis of LQZ-7 analogs, which can more effectively inhibit the survival of multiple human cancer cell lines with low micromolar IC50 (0.4–4.4 μM), suppress prostate PC3 xenograft tumors growth in vivo, and disrupt survivin dimerization. This evidence concerns the gene BIRC5 and cancer.