MAPK8 and breast carcinoma: A polyphenol extract from Annurca apples revealed an interesting antitumour mechanism in triple-negative MDA-MB-231 human breast carcinoma cells: the extract promoted ROS generation leading to c-Jun-N-terminal kinase (JNK) activation, thus promoting apoptosis and downregulated NF-κB, which is interconnected to JNK by reducing its apoptotic activity [58].