APOE and Alzheimer disease: Using a drug-repurposing algorithm, bumetanide was identified as the highest-ranking drug for APOE4/APOE4 AD, one of the most efficacious in reversing the transcriptomic signature of brain aging in APOE4-knock-in (KI) mice and was capable of rescuing LTP deficits in older APOE4-KI mice, which affects neuronal plasticity and memory formation [117].