HERC5 and neoplasm: Studies have shown that HERC5 is highly expressed in hepatocellular carcinoma tissues and cell lines, and researchers have screened a 7, 11-disubstituted quinazoline derivative, HZ-6d, which can bind to the HERC5 G-rich sequence and upregulate the expression level of the p53 protein, thus inhibiting tumor cell growth [80].