In addition, UHFR1 is highly expressed in HPV-positive cervical cancer cells, which negatively regulate UBCH8 by increasing the methylation on the UBCH8 gene promoter, and inhibiting UHRF1 can upregulate the expression of UBCH8, thereby promoting UBCH8-induced apoptosis [85]. The gene discussed is UBE2E2; the disease is cervical carcinoma.