Furthermore, Lin et al. found that HERC5 level is downregulated in colorectal cancer (CRC), and downregulation of HERC5 attenuates the ubiquitination of CtBP1, which then accumulates and assembles into a complex with histone deacetylase 1 and the transcription complex of the transcription factor c-Myc. Here, HERC5 is linked to colorectal carcinoma.