HERC5 and colorectal carcinoma: Overexpression of HERC5, downregulation of CtBP1, or blockade of CtBP1 function with its inhibitors (NSC95397 and 4-methylthio-2-oxobutyric acid [MTOB]) significantly prevents CRC cell proliferation in vitro and tumor growth in vivo [87] (Figure 6).