A multi-target activity 3D-QSAR model against acetylcholinesterase (AChE), serotonin transporter (SERT), beta-secretase 1 (BACE1) and glycogen synthase kinase-3 (GSK3β) was built to towards new therapeutics for Alzheimer’s disease [134]. The gene discussed is ACHE; the disease is early-onset autosomal dominant Alzheimer disease.