Furthermore, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) are considered indispensable mediators in glioma angiogenesis and can induce expression of the inhibitors for cell adhesion molecules [22] in non-glioma cells in both animal models and endothelial cells extracted from normal tissues [186,187,188,189]. The gene discussed is FGF2; the disease is central nervous system cancer.