For example, the circMAP3K5/miR-22-3p/TET2 axis might participate in the treatment of intimal hyperplasia-related diseases, including atherosclerosis [26]; circARHGAP12 ameliorated atherosclerosis progression through the miR-630/EZH2/TIMP2 axis [27]; melatonin inhibited aortic valve calcification through the circRIC3/miR-204-5p/DPP4 pathway in valvular interstitial cells [28]; and the circRNA-0006896/miR-1264/DNMT1 axis played a crucial role in plaque stabilization [29]. The gene discussed is DPP4; the disease is atherosclerosis.