The hepatoprotective effect shown by curcumin–andrographolide co-treatment, could be imputable to the observed upregulation of genes related to cell survival, such as V-AKT murine thymoma viral oncogene homolog 1 (AKT1), mitogen-activated protein kinase 8 (MAPK8), phosphoinositide-3-kinase, catalytic, alpha polypeptide (PIK3CA) (four times in respect to the steatosis control), and Fas, TNF receptor superfamily, member 6 (eight times). This evidence concerns the gene MAP3K8 and steatosis.