The compound also inhibited the activity of LRRK2, MELK, DYRK1B, CLK1, MNK2, TOPK, ROCK2, MSK2, p70S6K, PKG1a and CDK2–Cyclin A1 [71] and decreased the expression of TOPK, a kinase collaborating with FLT3 that is highly expressed in AML [82]. Here, PBK is linked to acute myeloid leukemia.