Treatment of AML cells with the small-molecule 2-indolylimidazole[4,5-d]phenanthroline derivative APTO-253 [105] induced CDKN1A expression, G0/G1 cell cycle arrest, and apoptosis through stabilization of G-quadruplex DNA, inhibition of MYC expression and induction of DNA damage [106]. Here, MYC is linked to acute myeloid leukemia.