KDR and acute leukemia: Aiming to improve the FLT3/CDK inhibitory activity, novel 1H-pyrazole-3-carboxamide derivatives were also developed from compound 50 [67]. Compound 8t had a multi-kinase inhibitory capacity, by targeting KDR/VEGFR2, ERK7, FLT1, FLT4 and GSK3 in addition to FLT3 and CDKs, that was responsible for its broad activity against acute leukemia but also solid tumor models.