In order to figure out changes in colon cancer cell lines at the molecular level after the observed growth-inhibitory effect of D. maritima bulb extract, RT-qPCR was applied to assess gene expression of multiple genes: Casp8, TNF-α, and IL-6 in COLO-205 and Caco-2 cells pre-treated with different concentrations of D. maritima bulb extract. This evidence concerns the gene CASP8 and colonic neoplasm.