Lipostatic effectInhibited lipogenesis, counteracting acne-inducing agents,Increased expression of ARHGAP9.Anti-proliferative actionIncrease of intracellular Ca2+ levels through TRPV4 agonism,Increased TRPV4 activation in initiating antiproliferative signaling cascade,Decreased level of MKI67.Anti-inflammatory effectChanged expression of the antimicrobial peptide LL-37 cathelicidin and TRIB3,Inhibition of the p65-NFκB pathway,RTeduced MKI67 marker expression. This evidence concerns the gene TRPV4 and acne.