By intensifying protein modifications, oxidative stress in psoriasis also modifies the enzymatic metabolism of phospholipids, resulting in the formation of bioactive lipid mediators, mainly endocannabinoids and eicosanoids [63,77,101], which act on G protein-related receptors, including CB1/CB2, TRPV1 and PPARs (β and γ), as well as receptor-independent mechanisms, affect keratinocyte growth and differentiation, as observed in patients with psoriasis [63,102,103]. This evidence concerns the gene CNR2 and psoriasis.