In head and neck squamous cell carcinoma, the VRK1 protein is positively correlated with several proliferation-related proteins including CDK2, CDK6, Cdc2, Cyclin B1/A, topoisomerase II (TOP2), survivin, and Ki67, suggesting that VRK1 can regulate the cell cycle [54]. The gene discussed is VRK1; the disease is head and neck squamous cell carcinoma.