Mecha-nistically, CMB showed anti-proliferative action towards OVCAR-3 and A-549 cancer cells through inducing apoptosis via a mitochondrial apoptotic pathway mediated by P53/Bax/Bcl-2 and caspase-3 along with arresting cell cycle at S phase via modulating the MAPK signaling pathway. The gene discussed is BCL2; the disease is cancer.