In an animal asthma model, the nAChR agonist 1,1-dimethyl-4-phenylpiperazinium (DMPP) was able to ameliorate the airway hyperresponsiveness, a characteristic of asthma, and airway inflammation in mice sensitized and challenged with ovalbumin (OVA) through cutting down lymphocyte and eosinophil numbers in the bronchoalveolar lavage fluid and mononuclear cell and eosinophil numbers in tissue immune cells infiltration [82]. Here, CHRNA4 is linked to asthma.