Zhang et al. found that the silencing of both α5nAChR and Ly6E, a member of the lymphocyte antigen 6 families and a factor in the regulation of TGF-β1/Smad signaling, can prevent NSCLC cancer cell migration, which has been confirmed in chicken embryo chorioallantoic membrane (CAM) and mouse xenograft models, and this finding may serve as a promising therapeutic intervention for non-small cell lung cancer [128]. This evidence concerns the gene LY6S and non-small cell lung carcinoma.