Significantly higher levels of amyloid protein precursor and total tau protein, increased tau protein phosphorylation, decreased hypoxia-inducible factor alpha [45,46], lower levels of amyloid degrading neprilysin, increased amyloid accumulation with activation of astrocytes and microglia have been shown in the brain after perinatal asphyxia [42,47]. This evidence concerns the gene MAPT and asphyxia.