al. demonstrated that celastrol dramatically reduced aortic valvular interstitial cell (AVIC) calcification in vitro by reducing NOX2 activity, and it greatly reduced the severity of aortic valve fibrosis, calcification, and stenosis in a rabbit model of calcific aortic valve disease (CAVD) in vivo [148]. The gene discussed is CYBB; the disease is congenital bilateral aplasia of vas deferens from CFTR mutation.