PIN1 and pancreatic ductal adenocarcinoma: Kazuhiro Koikawa et al. found that Pin1 was highly expressed in pancreatic ductal adenocarcinoma and cancer-associated fibroblasts (CAF), and that Pin1 inhibitor synergized with PD1 inhibitor αPD1 to promote apoptosis and significantly reduce tumor growth in human and KPC PDAC-like organoids in GDA mice [67].