Although the pathologic mechanisms of AD are not clearly elucidated, the pathologic hallmarks of AD are considered as the accumulation of beta-amyloid (Aβ) proteins in the form of senile plaques, the entanglement of hyperphosphorylated tau proteins in the form of neurofibrillary tangles, and loss of specific neurons [2,3,4]. This evidence concerns the gene MAPT and Alzheimer disease.