In the framework of our research on Boraginaceae plants [3,4,11,12,13], we herein present the phytochemical study on the aerial parts of H. procumbens from Panama in order to evaluate its chemical composition, the total phenolic and flavonoid content, antioxidant activity, inhibitory potentials against key clinical enzymes involved in neurodegenerative diseases (cholinesterases AChE, BChE), in skin whitening (tyrosinase), and in diabetes (α-amylase, α-glucosidase). Here, BCHE is linked to neurodegenerative disease.