LPA and familial hypercholesterolemia: According to “2016 ESC/EAS Guidelines for the Management of Dyslipidaemias”, Lp(a) concentrations should be considered for Lp(a) screening in selected high-risk cases for reclassification of subjects with borderline risk, with a class IIa indication and a level of evidence: C [231], specifically subjects with a family history of premature CVD, familial hypercholesterolemia and a family history of premature CVD and/or elevated Lp(a) levels, when Lp(a) is above the 80th percentile (50 mg/dL) [6].