The TRK family includes TRKA, TRKB, and TRKC proteins, encoded by the neurotrophic receptor tyrosine kinase 1 (NTRK1), NTRK2, and NTRK3 genes, respectively, and these NTRK gene fusions are oncogenic drivers of various adult and pediatric tumor types [156,157]. The gene discussed is NTRK2; the disease is neoplasm.