The results showed that MIP-NGs are considered as a promising therapeutic strategy for cadherin-mediated cancer, because the affinity of MIP-NGs towards the template peptides that are responsible for cancer cell–cell adhesion is more effective than that of commercially available antibodies in inhibiting cell adhesion assays, destroying 3D tumor spheroids, and inhibiting human cervical adenocarcinoma (HeLa) cell invasion. This evidence concerns the gene CDH17 and cancer.