CASP3 and breast carcinoma: For instance, Se-containing heterocycles, such as 1,2-[Bis(1,2-benzisoselenazolone-3-(2H)-ketone)] ethane (BBSKE), fosters the activity of caspase 3 against tongue cancer Tca8113 cell line [298]; 2,5-Bis(5-hydroxymethyl-2-selenienyl)-3-hydroxymethyl-N-methylpyrrole (D-501036) increases the activity of caspases 3 and 9 [299]; and methyl selenic acid activates caspases 8 and 9 in combination with tamoxifen in both tamoxifen-sensitive and tamoxifen-resistant breast cancer cells [289].