CD4 and neoplasm: On the other hand, an increased presence of T regulatory cells (Treg, CD4+CD25+FoxP3+) in the TME and a switch from the antitumor M1 to the protumor M2 phenotype of tumor-associated macrophages (TAMs) are considered as unfavorable events, because they stimulate tumor development and promote migration and extravasation [14,15].