Chromogranin A (CgA), neural cell adhesion molecule (CD56); neuron-specific enolase (NSE); and synaptophysin (Syn) are the most common neuroendocrine markers that can be detected by immunohistochemistry, which are frequently used in the differential diagnosis of neuroendocrine carcinoma [4,9,16,17,18]. The gene discussed is ENO2; the disease is neuroendocrine carcinoma.