On the other hand, the PON1 gene polymorphisms of 192 Gln/Arg and 55 Leu/Met in the amino-acid sequence partially alter the enzymatic activity of PON1 against paraoxon and not against arylesterase (i.e., 192 Gln/Arg QQ homozygotes have a lower activity of paraoxonase) [53,54,55] and we can assume such genetic effects on CKD stages. The gene discussed is PON1; the disease is chronic kidney disease.