Rattanasupar et al. tried to define clinical predictors of HE in cirrhotic patients presenting with acute variceal bleeding [34]; according to their retrospective study, Child-Pugh score C, serum levels of potassium < 3 mEq/L, white blood cells count > 10,000/mm3 and Hb < 8 g/dL were considered significant predictors of the development of HE. Here, GSTM1 is linked to hereditary elliptocytosis.