The increased cardiovascular risk in CKD patients may be attributed to hypertension that may occur due to the activation of the renin–angiotensin–aldosterone system, vascular calcification associated with abnormal metabolism of calcium and phosphorus, and the specific dyslipidemia of CKD, chronic inflammation, malnutrition, oxidative stress, and uremic factors [7,8]. The gene discussed is REN; the disease is chronic kidney disease.