Moreover, the levels of ALC (1.36 (0.99, 2.01) vs. 1.13 (0.80,1.63)), CRP (57.30 (9.80, 90.30) vs. 35.40 (8.51, 80.42)), IL-6 (70.30 (11.57, 101.99) vs. 42.53 (12.93, 64.47)), fibrinogen (4.95 (3.66, 5.66) vs. 3.97 (3.07, 4.98)), complement C3 (0.969 (0.852, 1.100) vs. 0.895 (0.765, 0.975)) and C4 (0.235 (0.191, 0.279) vs. 0.204 (0.163, 0.246)) in LC patients were much higher than those in patients without cancer (p < 0.05). Here, C3 is linked to laryngotracheoesophageal cleft.