In two patients who were already carriers of a pathogenic variant in LDLR that could solely explain their FH phenotype, an additional VUS was found: one was a carrier of the P variant LDLR p.Gly592Glu and a VUS (LDLR Arg253Gln); and another was a carrier of the P variant LDLR p.Glu288Lys and a VUS in APOB (APOB Asp1908Asn). This evidence concerns the gene LDLR and familial hyperaldosteronism.