More pertinently, we detected statistically significantly higher RANK-L levels in the periodontitis III/IV (49.14 ± 19.55 pg/mL) and periodontitis I/II patients (37.10 ± 10.88 pg/mL) compared to the periodontally healthy controls (28.18 ± 9.68 pg/mL) (p < 0.001). Here, TNFSF11 is linked to periodontitis.