When we correlated the immunomediators with the clinical parameters within the different grades of periodontitis, we found that in the grade A periodontitis patients, the total PPD was positively and statistically significantly correlated with the OPG (r = 0.873; p < 0.05), while the biomarker IL-1β correlated strongly and statistically significant positively with the PI percentage (r = 0.927; p < 0.01) and PPD (r = 0.873; p < 0.05) (Table 6). This evidence concerns the gene TNFRSF11B and periodontitis.