The ANOVA analysis showed that the patients with grade C periodontitis presented a significantly higher mean level of RANK-L [50.72 ± 20.10 pg/mL] compared with the grade B periodontitis [38.03 ± 10.89 pg/mL] and grade A periodontitis [35.28 ± 9.58 pg/mL] (p = 0.035) patients (Figure 1). Here, TNFSF11 is linked to periodontitis.