Direct activation of CLL cells might rather be inducedthrough the TLR7 pathway asCLL cells are activated through the TLRs (e.g., TLR7), and RNA from SARS-CoV-2 has beenfound in the lymph nodes and spleen of infected individuals (Figure 1, bottom left) [2,31]. The gene discussed is TLR7; the disease is B-cell chronic lymphocytic leukemia.