EGFR and large cell neuroendocrine carcinoma: However, pulmonary combined SCLC and combined large-cell neuroendocrine carcinoma (combined LCNEC) were noted to possess different interacting driver genes, as exemplified by the lower incidence of EGFR mutations in combined SCLC than in combined LCNEC (5% vs. 25.7%, p = 0.004) [18].