In vitro experiments using keratinocytes obtained from the normal unaffected skin of 29 CLE patients showed that the keratinocytes from SLE and SCLE patients were more sensitive to UV radiation than healthy keratinocytes and showed enhanced susceptibility to antibody-dependent cell-mediated cytotoxicity (ADCC) by autologous patient’s serum or anti-SS-A/Ro+ serum [48]. The gene discussed is RO60; the disease is systemic lupus erythematosus.