RO60 and systemic lupus erythematosus: In vivo studies confirmed that the monocolonization of the mouse gut with Ro60 ortholog-producing commensal bacteria triggered lupus-like symptoms, including the production of anti-human Ro60 autoantibodies and the development of glomerular immune complex deposits, suggesting that commensal Ro60 ortholog cross-reactivity is involved in the pathogenesis of lupus [15].