Finally, a CRP increase of at least 200% in patients with CS within the first 3 days was associated with an increased risk of 30-day all-cause mortality compared to patients with a CRP increase of less than 200% (51% vs. 35%; log-rank p = 0.040; HR = 1.720; 95% CI 1.006–2.943; p = 0.048) (Figure 4). Here, CRP is linked to Cowden syndrome 1.