Increasing intracellular Ca2+ concentration can reduce cell viability and interleukin (IL)-6/IL-8/matrix metalloproteinase (MMP)-3 production of RA synovial fibroblasts (RASF) [54], increase IKAROS (encoded by IKZF1) expression [55], and reduce joint inflammation [56]. Here, MMP3 is linked to rheumatoid arthritis.