Increasing intracellular Ca2+ concentration can reduce cell viability and interleukin (IL)-6/IL-8/matrix metalloproteinase (MMP)-3 production of RA synovial fibroblasts (RASF) [54], increase IKAROS (encoded by IKZF1) expression [55], and reduce joint inflammation [56]. The gene discussed is CXCL8; the disease is rheumatoid arthritis.