VWF and endothelial dysfunction: Moreover, von Willebrand factor, a marker of endothelial dysfunction/activation participating to hemostasis, is elevated along with the severity of the liver disease, correlates with portal pressure, and endotoxemia, and has been consistently associated with prognosis, suggesting that endothelial damage and over-activation of hemostasis could be pathogenic mediators of liver damage [17,21,24,25].