DSP and Microcephaly - facio-cardio-skeletal syndrome, Hadziselimovic type: Cardiocutaneous syndrome (CCS) is often caused by genetic variants in desmoplakin (<i>DSP</i>) in the presence of thick calluses on the hands and soles of the feet (palmoplantar keratoderma) in combination with arrhythmogenic cardiomyopathy.