Given that the patterns of serum HHIP levels and their relationship with obesity, IR, and metabolic parameters were in contrast to those of adipoq in the women with IR and PCOS included in our cohort, we hypothesized that the role of HHIP in metabolic disorders may be different from that of adipoq, that is, HHIP promotes rather than improves IR. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.