HLA-C and neoplasm: The receptor detects various tumor cell-related antigens, most of which are a degraded form of major histocompatibility complex (MHC) class I antigens, such as MHC class I chain-related protein A and B (MICA and MICB), UL16-binding proteins in humans, retinoic acid early inducible-1 (RAE1) family protein, and mouse UL-16-binding protein-like transcript 1 (MULT-1) in mice [5].