Interestingly, this effect is independent of antitumor immunity induced by the IFN-γ-perforin-granzyme pathway; because cytotoxicity against liver and tumor cells is independently regulated, hepatotoxicity is blocked by prior administration of anti-TNF or anti-FasL antibodies without attenuating cytotoxicity against tumor cells [50]. The gene discussed is PRF1; the disease is neoplasm.