Platelets may also induce the lesional expression of thymic stromal lymphopoietin (TSLP) through platelet-derived IL-1β [198,199] and drive type 2 immunity that facilitates lesional fibrogenesis [169,198], similar to how platelets induces endothelial TSLP expression to promote fibrogenesis in human systemic sclerosis [199]. This evidence concerns the gene TSLP and systemic sclerosis.