TF and endometriosis: In fact, it has been reported that increased production of thromboxane B2 (TXB2), a metabolite of TXA2, by endometriotic stromal cells stimulated with IL-1β, increases TF expression as well as thrombin concentration in peritoneal fluids from women with endometriosis [151], suggesting that endometriotic and perhaps adenomyotic lesion as well and its microenvironment are conducive to platelet activation and aggregation.