After adjusting more confounding factors by multivariate logistic regression analysis, the results showed that the G4 subgroup of TNF-α and the G3 subgroup of IL-6 were independent risk factors for poor functional prognosis in MMD (OR 4.626, 95% CI [1.493, 14.337], p = 0.008; OR 4.794, 95% CI 4.794, p = 0.004). This evidence concerns the gene TNF and multiminicore myopathy.